Applications

One pump platform.
Every chromatography workflow.

From bench analytical separation to GMP-scale biopurification, CRS Scientific piston pumps are integrated into instruments solving real problems for scientists every day.

Analytical HPLC

Sub-µL/min stability and 60 MPa pressure ratings make CRS-HP the workhorse pump behind isocratic, binary, and quaternary analytical HPLC systems used across pharma QC, environmental, and food safety labs.

  • Sub-percent retention time RSD
  • Compatible with USP <621> methods
  • Tight gradient delay volume

UHPLC

Hardened sapphire plungers, redundant check valves, and intelligent compressibility correction enable CRS pumps to drive sub-2µm columns to their full performance envelope.

  • Pressures sustained at 60 MPa
  • Fast gradient ramp times
  • Low delay volume design

FPLC / Protein Purification

Bioinert PEEK and titanium flow paths protect biologics. Continuous rear-rinsed seals prevent salt crystallization, so high-conductivity gradients don't punish your seals.

  • USP Class VI material options
  • Salt-tolerant seal architecture
  • Low-pulsation gradient mixing

Preparative HPLC

From semi-prep purification of natural products to scale-up of API intermediates, the CRS-FB platform delivers reproducible volumetric flow up to 300 ml/min at 30 MPa.

  • Extended seal life under solvent load
  • Stable flow during fraction collection
  • Field-replaceable head assemblies

Flash Chromatography

Rugged dual-piston design, simple maintenance, and a price point that fits flash instrument BOMs — CRS-FB is the right pump for high-throughput purification environments.

  • Tolerant of particulate-rich solvents
  • Quick prime and self-flush routines
  • Compact OEM footprint

SFC & SMB

Specialty chromatography modes demand specialty pumps. CRS supplies CO₂-rated pump heads for SFC and balanced multi-pump configurations for simulated moving bed systems.

  • CO₂-compatible head options
  • Synchronized multi-pump control
  • Closed-loop pressure regulation

Process-scale Bioprocessing

CRS-LP large-bore pumps are integrated into downstream bioprocessing skids, providing reliable buffer and product flow up to 1 L/min with industrial communication protocols.

  • 24/7 continuous duty
  • EtherCAT, Modbus, OPC-UA
  • GMP documentation available

LC-MS Front End

Low-volume, MS-friendly pump configurations with metal-free wetted parts options serve as the front end for high-sensitivity LC-MS/MS systems.

  • Metal-free flow path options
  • Low carryover, low delay volume
  • Cleanly integrates with autosamplers

Continuous Flow Chemistry

Beyond chromatography — CRS piston pumps are deployed as reagent metering pumps in continuous flow synthesis, PET radiochemistry, and process analytics.

  • Precise µL/min metering
  • Chemically resistant materials
  • Closed-loop flow feedback

Don't see your application?

If you can measure it, we can probably pump it. Let's discuss your fluidic challenge.

Talk to Engineering