Applications

One pump platform.
Every chromatography workflow.

From bench analytical separation to GMP-scale biopurification, CRS Scientific piston pumps are integrated into instruments solving real problems for scientists every day.

How it works

The piston pump anatomy.

Every CRS pump shares the same core mechanical principle — a precision sapphire plunger reciprocating in a stainless-steel chamber, with ceramic check valves controlling flow direction. What changes between application platforms is the materials, dimensions, and sealing strategy.

Reciprocating piston pump cross-section showing sapphire plunger, plunger seal, pump chamber, and inlet/outlet check valves

Analytical HPLC

Sub-µL/min stability and 60 MPa pressure ratings make CRS-HP the workhorse pump behind isocratic, binary, and quaternary analytical HPLC systems used across pharma QC, environmental, and food safety labs.

  • Sub-percent retention time RSD
  • Compatible with USP <621> methods
  • Tight gradient delay volume

UHPLC

Hardened sapphire plungers, redundant check valves, and intelligent compressibility correction enable CRS pumps to drive sub-2µm columns to their full performance envelope.

  • Pressures sustained at 60 MPa
  • Fast gradient ramp times
  • Low delay volume design

FPLC / Protein Purification

Bioinert PEEK and titanium flow paths protect biologics. Continuous rear-rinsed seals prevent salt crystallization, so high-conductivity gradients don't punish your seals.

  • USP Class VI material options
  • Salt-tolerant seal architecture
  • Low-pulsation gradient mixing

Preparative HPLC

From semi-prep purification of natural products to scale-up of API intermediates, the CRS-FB platform delivers reproducible volumetric flow up to 300 ml/min at 15 MPa.

  • Extended seal life under solvent load
  • Stable flow during fraction collection
  • Field-replaceable head assemblies

Flash Chromatography

Rugged dual-piston design, simple maintenance, and a price point that fits flash instrument BOMs — CRS-FB is the right pump for high-throughput purification environments.

  • Tolerant of particulate-rich solvents
  • Quick prime and self-flush routines
  • Compact OEM footprint

SFC & SMB

Specialty chromatography modes demand specialty pumps. CRS supplies CO₂-rated pump heads for SFC and balanced multi-pump configurations for simulated moving bed systems.

  • CO₂-compatible head options
  • Synchronized multi-pump control
  • Closed-loop pressure regulation

Process-scale Bioprocessing

CRS-LP large-bore pumps are integrated into downstream bioprocessing skids, providing reliable buffer and product flow up to 1 L/min with industrial communication protocols.

  • 24/7 continuous duty
  • EtherCAT, Modbus, OPC-UA
  • GMP documentation available

LC-MS Front End

Low-volume, MS-friendly pump configurations with metal-free wetted parts options serve as the front end for high-sensitivity LC-MS/MS systems.

  • Metal-free flow path options
  • Low carryover, low delay volume
  • Cleanly integrates with autosamplers

Continuous Flow Chemistry

Beyond chromatography — CRS piston pumps are deployed as reagent metering pumps in continuous flow synthesis, PET radiochemistry, and process analytics.

  • Precise µL/min metering
  • Chemically resistant materials
  • Closed-loop flow feedback

Don't see your application?

If you can measure it, we can probably pump it. Let's discuss your fluidic challenge.

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